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Schizophrenia Bulletin Advance Access published online on April 2, 2007
Schizophrenia Bulletin, doi:10.1093/schbul/sbm021
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© The Author 2007. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Anti-Toxoplasma gondii Antibodies in Patients With Schizophrenia—Preliminary Findings in a Turkish Sample

Zafer Cetinkaya2, Suleyman Yazar1,3, Omer Gecici4 and Mustafa N. Namli5
2 Department of Microbiology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey
3 Department of Parasitology, Faculty of Medicine, Erciyes University, 38039-Kayseri, Turkey
4 Department of Psychiatry, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey
5 Elazig Mental State Hospital, Elazig, Turkey

1 To whom correspondence should be addressed; tel: 90-352-4374937/23401, fax: 90-352-4375285, e-mail: syazar{at}erciyes.edu.tr.

Schizophrenia is a serious neuropsychiatric disease of uncertain etiology. We investigated the seropositivity rate for anti-Toxoplasma IgG and IgM antibodies by enzyme-linked immunosorbent assay (ELISA) in patients with schizophrenia to ascertain a possible relationship between Toxoplasma gondii and schizophrenia. We selected 100 patients with schizophrenia, 50 with depressive disorder, and 50 healthy volunteers to investigate the seropositivity rate of anti-Toxoplasma antibodies by ELISA. The seropositivity rate for anti-Toxoplasma IgG antibodies among schizophrenia patients (66%) was significantly higher than among patients with depressive disorder or healthy volunteers (P < .01). Thus, there might be a causal relationship between toxoplasmosis and the etiology of schizophrenia.

Keywords: schizophrenia / Toxoplasma gondii / ELISA


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