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Schizophrenia Bulletin Advance Access published online on April 13, 2007
Schizophrenia Bulletin, doi:10.1093/schbul/sbm030
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© The Author 2007. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Toxoplasma gondii and Schizophrenia: Linkage Through Astrocyte-Derived Kynurenic Acid?

Robert Schwarcz1 and Christopher A. Hunter2
2 Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104

Keywords: infection / kynurenine / parasite

The first 10% of the full text of this article appears below.

Toxoplasma gondii is a ubiquitous food- and water-borne parasite that in most individuals is able to persist in multiple tissues, including the central nervous system (CNS), without causing an apparent clinical disease.1 During the chronic phase of toxoplasmosis, the latent stage of the parasite is found in the CNS, and studies from murine models have established that long-term resistance to the parasite is dependent on the ability to generate and maintain parasite-specific CD4+ and CD8+ T cells. Consistent with this observation, patients with primary or acquired defects in T cell–mediated immunity are susceptible to . . . [Full Text of this Article]

1 To whom correspondence should be addressed; Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228; tel: +1-410-402-7635, fax: +1-410-747-2434, e-mail: rschwarc@mprc.umaryland.edu.


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