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Schizophrenia Bulletin Advance Access published online on July 13, 2007
Schizophrenia Bulletin, doi:10.1093/schbul/sbm079
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© The Author 2007. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

A Social Deafferentation Hypothesis for Induction of Active Schizophrenia

Ralph E. Hoffman1,2
2 Department of Psychiatry, Yale University School of Medicine

1 To whom correspondence should be addressed; Yale-New Haven Psychiatric Hospital, 184 Liberty Street, New Haven, CT 06519; tel: 203-688-9734, fax: 203-688-9709, e-mail: Ralph.hoffman{at}yale.edu.

The "social brain" of humans reflects widespread neural resources dedicated to understanding the conversational language, emotionality, states of mind, and intentions of other persons. A social deafferentation (SDA) hypothesis for induction of active schizophrenia is proposed. Analogous to hallucinations produced by sensory deafferentation, such as phantom limb, the SDA hypothesis assumes that high levels of social withdrawal/isolation in vulnerable individuals prompt social cognition programs to produce spurious social meaning in the form of complex, emotionally compelling hallucinations and delusions representing other persons or agents. Arguments against the SDA hypothesis are discussed, and predictions deriving from the hypothesis are offered.

Keywords: social cognition / auditory hallucinations / delusions / social withdrawal


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