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Schizophrenia Bulletin Advance Access published online on July 18, 2007
Schizophrenia Bulletin, doi:10.1093/schbul/sbm082
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© The Author 2007. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Identifying Unmet Therapeutic Domains in Schizophrenia Patients: The Early Contributions of Wayne Fenton From Chestnut Lodge

Thomas H. McGlashan3 and William T. Carpenter1,2
2 Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228
3 Department of Psychiatry, Yale University

1 To whom correspondence should be addressed; tel: 410-402-7101, fax: 410-788-3837, e-mail: wcarpent{at}mprc.umaryland.edu.

Wayne Fenton, MD, died on September 3, 2006, while giving emergency clinical care. His leadership at National Institute of Mental Health provided a framework for therapeutic discovery. He crafted a new approach to psychosis based on poor functional outcomes and the psychopathology domains underlying long-term morbidity. His research and clinical observations during his career at the Chestnut Lodge clarified the unmet therapeutic needs in schizophrenia and provided the foundation for his vision. The results have radically changed the paradigm for discovery with emphasis on impaired cognition and negative symptom psychopathology.

Keywords: psychopathology / schizophrenia / cognition / negative symptoms / Fenton


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