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Schizophrenia Bulletin Advance Access first published online on February 8, 2008
This version published online on February 14, 2008
Schizophrenia Bulletin, doi:10.1093/schbul/sbm164
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© The Author 2008. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

The Concept of Progressive Brain Change in Schizophrenia: Implications for Understanding Schizophrenia

Lynn E. DeLisi1,3
2 New York University School of Medicine, 650 First Avenue, New York, NY 1006
3 Center for Advanced Brain Imaging, The Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962

1 To whom correspondence should be addressed; tel: 212-263-3406; fax: 212-263-3407; e-mail: DeLisi76{at}AOL.com.

Kraepelin originally defined dementia praecox as a progressive brain disease, although this concept has received various degrees of acceptance and rejection over the years since his famous published textbooks appeared. This article places an historical perspective on the current renewal of Kraepelin's concept in brain imaging literature that supports progressive brain change in schizophrenia from its earliest stages through its chronic course. It is concluded that a great deal of future research is needed focusing on the longitudinal course of change, the extent to the regions of change within each individual and the underlying mechanism and implications of brain change through functional and neurochemical imaging, combined with structural studies in the same individuals.

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