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Schizophrenia Bulletin Advance Access published online on May 30, 2008
Schizophrenia Bulletin, doi:10.1093/schbul/sbn051
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© The Author 2008. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Comparing Genes and Phenomenology in the Major Psychoses: Schizophrenia and Bipolar 1 Disorder

Elena Ivleva2, Gunvant Thaker3 and Carol A. Tamminga1,2
2 Department of Psychiatry, University of Texas Southwestern Medical School, 5352 Harry Hines Boulevard, Dallas, TX 75235
3 Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD

The first 150 words of the full text of this article appear below.


   Classifying Psychotic Disorders
 
For the last several decades, diagnosis in psychiatry has been rule based, related to phenomenology and standardized. It has given psychiatry an unearned advantage in communicating about its illnesses, unearned because the molecular basis for this standardization has remained elusive. However, it has provided a language for successful communication about psychiatric syndromes and supported practical functions for which categorization is helpful; functions as disparate as insurance reimbursement and drug development have been enabled with this language. Moreover, this standardization has had additional practical advantages beyond communication and labeling, specifically in terms of public familiarity.

Further, these standardized categories have been postulated without any real knowledge about the biological nature of the underlying brain disturbances or their mechanisms. Imagine categorizing diabetes by phenomenology before 1922 or infectious disease before the microscope and antibiotics. It is hard to intuit how one might successfully use nonspecific illness descriptors of phenomenology to sort affected . . . [Full Text of this Article]


   The Bipolar Disorder-Schizophrenia Distinction
 

   The Phenomenology of Psychosis as a Component Symptom Complex
 

   Psychosis Genetics
 
Family Studies
Twin Studies
Genetic Linkage Studies
Studies of Individual Genes

   Conclusions
 
1 To whom correspondence should be addressed; tel: 214-645-2789; fax: 214-645-2786, e-mail: Carol.tamminga@utsouthwestern.edu.


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