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Schizophrenia Bulletin Advance Access published online on August 14, 2008
Schizophrenia Bulletin, doi:10.1093/schbul/sbn105
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© The Author 2008. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Environmental Studies of Schizophrenia Through the Prism of Epigenetics

Gabriel Oh2 and Arturas Petronis1,2
2 The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario M5T 1R8, Canada

1 To whom correspondence should be addressed; tel: 416-535-8501 ext 4880, fax: 416-979-4666, e-mail: arturas_petronis{at}camh.net.

Traditionally, etiological research of schizophrenia has been focused on elucidating predisposing genes and environmental risk factors. While numerous putative environmental hazards have been suggested, inconsistencies and methodological limitations of epidemiological studies have made it difficult to identify even a single exogenous cause of schizophrenia. Furthermore, there is increasing evidence that environmental risk factors may not play as much of a significant role in schizophrenia as previously suspected. In this article, we argue that molecular epigenetic studies can overcome the complexities of traditional epidemiological studies and may become a productive line of research in understanding the nongenetic mechanisms of schizophrenia.

Keywords: schizophrenia / epidemiology / environment / epigenetics / DNA methylation


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