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Schizophrenia Bulletin Advance Access published online on November 5, 2008
Schizophrenia Bulletin, doi:10.1093/schbul/sbn143
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© The Author 2008. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Clinical Recovery in First-Episode Psychosis

Lex Wunderink1,2, Sjoerd Sytema2, Fokko J. Nienhuis2 and Durk Wiersma2
2 University Medical Center Groningen, University Psychiatric Center, University of Groningen, The Netherlands

1 To whom correspondence should be addressed; University Medical Center Groningen, University Psychiatric Center (5.21), University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands; tel: +31-50-361-1136, fax: +31-50-361-9722, e-mail: a.wunderink{at}med.umcg.nl

Introduction: Generally agreed outcome criteria in psychosis are required to evaluate the effectiveness of new treatment strategies. The aim of this study is to explore clinical recovery in first-episode patients, defined by meeting criteria for both symptomatic and functional remission. Method: In a sample of first-episode patients (N = 125), symptomatic and functional remission during the last 9 months of a 2-year follow-up period were examined, as well as recovery and its predictors. Results: Half the patients (52.0%) showed symptomatic remission and a quarter (26.4%) functional remission, while one-fifth (19.2%) met both criteria sets and were considered recovered. Recovery was significantly associated with short duration of untreated psychosis and better baseline functioning. Conclusion: Most functionally remitted patients were also symptomatically remitted, while a minority of symptomatically remitted patients were also functionally remitted. Treatment delay may affect chance of recovery.

Keywords: schizophrenia / remission / social functioning / disability / duration of untreated psychosis


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