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Schizophrenia Bulletin Advance Access first published online on March 26, 2009
This version published online on April 2, 2009
Schizophrenia Bulletin, doi:10.1093/schbul/sbp016
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© 2009 The Authors
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Substance Use Disorders in Schizophrenia—Clinical Implications of Comorbidity

Nora D. Volkow1,2
2 National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD

1 To whom correspondence should be addressed; Office of the Director, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 5274, MSC 9581, Bethesda, MD 20892; tel: 301-443-6480, fax: 301-443-9127, e-mail: nvolkow{at}nida.nih.gov.

Nearly half of the people suffering from schizophrenia also present with a lifetime history of substance use disorders (SUD), a rate that is much higher than the one seen among unaffected individuals. This phenomenon suggests that the factors influencing SUD risk in schizophrenia may be more numerous and/or complex than those modulating SUD risk in the general population. It is critically important to address this comorbidity because SUD in schizophrenic patients is associated with poorer clinical outcomes and contributes significantly to their morbidity and mortality.

Keywords: schizophrenia / substance use disorders / comorbidity

"Updated to remove "Editorial" from title".


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